Extracellular Regucalcin: A Potent Suppressor in the Cancer Cell Microenvironment
Published by
Cancers
Summary
Published research article.
Masayoshi Yamaguchi
Distinguished Research Professor & Cancer Biologist
Honolulu, US.About
Distinguished Research Professor and Cancer Biologist with over 50 years of pioneering contributions in endocrinology and cell signaling, currently at the University of Hawaii Cancer Center. Discovered critical proteins regucalcin and RGPR-p117, demonstrating regucalcin's role as a cancer suppressor. Authored over 600 peer-reviewed articles, secured 25 international patents, and served on 90+ editorial boards, advancing global understanding in biochemistry, molecular biology, and cancer research.
Work
University of Hawaii Cancer Center, University of Hawaii at Manoa
|Professor, Cancer Biology
Honolulu, Hawaii, US
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Summary
Leads advanced research in cancer biology and molecular metabolism, contributing to groundbreaking discoveries and scientific literature.
Highlights
Continues pioneering research in cell signaling mechanisms, bone biology, and cancer metastasis, focusing on novel therapeutic targets.
Directs studies on the functional implications of regucalcin, demonstrating its suppressive role in human cancer carcinogenesis.
Contributes to a robust publication record of over 600 English articles in professional journals, significantly influencing the scientific community.
Serves as an active editorial board member for over 90 international journals, including Current Cancer Drug Targets and Cancers, shaping global research discourse.
University of Hawaii Cancer Center, University of Hawaii at Manoa
|Adjunct Professor, Cancer Biology
Honolulu, Hawaii, US
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Summary
Provided expert guidance and collaborative research support in cancer biology at a leading research institution.
Highlights
Contributed to ongoing research initiatives in cancer biology, leveraging extensive expertise in endocrinology and cell signaling.
Collaborated with interdisciplinary teams to advance understanding of molecular mechanisms underlying cancer development.
Supported the research mission through academic contributions and mentorship, fostering scientific excellence.
David Geffen School of Medicine, University of California, Los Angeles (UCLA)
|Visiting Professor, Department of Pathology and Laboratory Medicine
Los Angeles, California, US
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Summary
Conducted specialized research and delivered academic insights in pathology and laboratory medicine at a top-tier medical school.
Highlights
Engaged in advanced research on molecular pathology, applying expertise in cell signaling and metabolism to clinical problems.
Collaborated on studies investigating disease mechanisms within the Department of Pathology and Laboratory Medicine.
Provided academic contributions and shared specialized knowledge with faculty and students.
Emory University School of Medicine
|Adjunct Professor, Department of Hematology and Medical Oncology
Atlanta, Georgia, US
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Summary
Contributed specialized knowledge in hematology and medical oncology to a distinguished academic medical center.
Highlights
Supported research on hematological malignancies and solid tumor oncology, applying biochemical and molecular insights.
Participated in academic discussions and research projects focused on improving cancer treatment strategies.
Leveraged extensive background in molecular biology to inform research directions within the department.
Baylor College of Medicine
|Visiting Professor in Division of Diabetes, Endocrinology and Metabolism, Department of Medicine
Houston, Texas, US
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Summary
Shared expertise in diabetes, endocrinology, and metabolism, fostering collaborative research and academic exchange.
Highlights
Contributed to research on metabolic disorders and endocrine diseases within the Division of Diabetes, Endocrinology and Metabolism.
Collaborated with faculty on studies exploring novel therapeutic approaches and disease mechanisms.
Delivered lectures and participated in seminars, enriching the academic environment.
The University of Missouri-Columbia
|Visiting Professor, Department of Pathobiology, College of Veterinary Medicine
Columbia, Missouri, US
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Summary
Provided specialized insights in pathobiology and veterinary medicine through academic engagement.
Highlights
Contributed to research in pathobiology, applying advanced knowledge of molecular and cellular mechanisms.
Engaged in interdisciplinary discussions focused on disease etiology and progression.
Shared expertise with students and faculty in relevant research areas.
The University of Georgia
|Visiting Professor, Department of Foods and Nutrition
Athens, Georgia, US
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Summary
Shared expertise in foods and nutrition, contributing to research and academic programs.
Highlights
Contributed to studies on the impact of nutrition on metabolic health and disease prevention.
Collaborated on research projects within the Department of Foods and Nutrition.
Provided academic insights into the biochemical aspects of dietary components.
Emory University School of Medicine
|Visiting Professor, Division of Endocrinology and Metabolism and Lipids, Department of Medicine
Atlanta, Georgia, US
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Summary
Contributed advanced knowledge in endocrinology, metabolism, and lipids to research and academic initiatives.
Highlights
Conducted research on lipid metabolism and endocrine regulation, publishing findings in peer-reviewed journals.
Collaborated with faculty on investigations into the molecular basis of metabolic disorders.
Mentored junior researchers, fostering their development in specialized scientific areas.
University of Shizuoka
|Professor, Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences
Shizuoka, Shizuoka Prefecture, Japan
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Summary
Led extensive research and academic programs in endocrinology, molecular metabolism, and pharmaceutical sciences, making seminal discoveries.
Highlights
Pioneered research in biochemistry, molecular biology, endocrinology, metabolism, nutrition, pharmacology, and toxicology, establishing a broad scientific foundation.
Guided numerous graduate students and researchers, fostering a culture of scientific inquiry and innovation.
Authored a significant portion of the 600+ peer-reviewed articles, contributing substantially to the body of scientific knowledge.
Secured 25 national and international patents related to novel research findings, demonstrating practical application of discoveries.
University of Shizuoka
|Associate Professor, Graduate School of Nutritional Sciences
Shizuoka, Shizuoka Prefecture, Japan
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Summary
Conducted advanced research and taught in nutritional sciences, contributing to the academic and scientific mission of the university.
Highlights
Contributed to the discovery of the transcriptional factor RGPR-p117 (2001), significantly advancing gene regulation research.
Developed and delivered curriculum in nutritional sciences, guiding students in complex molecular and metabolic topics.
Collaborated on interdisciplinary research projects, enhancing the university's scientific output.
Published research findings in peer-reviewed journals, contributing to the global scientific discourse.
University of Shizuoka
|Assistant Professor, School of Pharmaceutical Sciences
Shizuoka, Shizuoka Prefecture, Japan
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Summary
Initiated and conducted research in pharmaceutical sciences, contributing to foundational discoveries and academic programs.
Highlights
Pioneered early research in cell signaling mechanisms, bone biology, and cancer biology, establishing key research interests.
Mentored junior researchers and students, fostering their development in scientific methodology and critical thinking.
Contributed to the academic curriculum within the School of Pharmaceutical Sciences.
Published initial research findings, laying the groundwork for subsequent major discoveries.
The University of Texas Medical School at Houston
|Visiting Assistant Professor
Houston, Texas, US
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Summary
Engaged in collaborative research and academic activities within a medical school setting.
Highlights
Contributed to research projects, applying expertise in pharmaceutical sciences and biochemistry.
Collaborated with faculty on studies related to medical sciences.
Gained international research experience, broadening scientific perspective.
Shizuoka College of Pharmacy
|Assistant Professor
Shizuoka, Shizuoka Prefecture, Japan
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Summary
Contributed to academic instruction and research initiatives within the pharmaceutical sciences.
Highlights
Participated in teaching and mentorship activities for students in pharmaceutical sciences.
Engaged in research focused on endocrinology and cell signaling, building expertise in these areas.
Collaborated with senior faculty on scientific investigations, contributing to the college's research output.
Shizuoka College of Pharmacy
|Research Associate
Shizuoka, Shizuoka Prefecture, Japan
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Summary
Conducted foundational research in pharmaceutical sciences, laying the groundwork for future discoveries.
Highlights
Initiated research in endocrinology and cell signaling in 1971, which formed the basis of a lifelong research trajectory.
Contributed to early studies that led to the discovery of regucalcin (1978), a seminal finding in cell biology.
Developed expertise in biochemical and molecular techniques, supporting a wide range of scientific investigations.
Collaborated on projects that advanced understanding in pharmaceutical sciences.
Texas Tech University School of Medicine
|Visiting Assistant Professor
Lubbock, Texas, US
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Summary
Participated in research and academic initiatives within a medical school environment.
Highlights
Engaged in research collaborations, contributing specialized knowledge to medical studies.
Supported scientific investigations, enhancing understanding of complex biological processes.
Expanded professional network within the US academic medical community.
The University of Pennsylvania School of Medicine
|Visiting Lecturer
Philadelphia, Pennsylvania, US
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Summary
Delivered lectures and contributed to academic discourse at a prestigious medical institution.
Highlights
Shared expertise on specific research topics with medical students and faculty.
Participated in academic discussions, contributing to the intellectual environment.
Gained early international lecturing experience at a renowned university.
Education
Shizuoka College of Pharmacy
Shizuoka, Shizuoka Prefecture, Japan
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PhD
Pharmaceutical Sciences
Shizuoka College of Pharmacy
Shizuoka, Shizuoka Prefecture, Japan
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B.S.
Pharmaceutical Sciences
Awards
Distinguished Scientist Award
Awarded By
India
Recognition for significant scientific contributions and global impact in research.
The 2017 Albert Nelson Marquis Lifetime Achievement Award
Awarded By
Marquis Who's Who, USA
Honored for exceptional career longevity and profound impact in scientific research and academia.
Japan Society for Biomedical Research on Trace Elements Award
Awarded By
Japan Society for Biomedical Research on Trace Elements
Awarded for significant research contributions in the field of trace elements within biomedical science.
Senji Miyata Foundation Award
Awarded By
Senji Miyata Foundation, Japan
Recognized for outstanding contributions to biomedical research and scientific advancements.
The Lifetime Achievement Award
Awarded By
International Biographical Centre (IBC), England
Celebrated for a career-long dedication and impactful contributions across scientific endeavors.
The World Lifetime Achievement Award
Awarded By
American Biographical Institute, USA
Honored for profound and lasting contributions to the global scientific community and research.
Prize for Sato Memorial Foundation
Awarded By
Sato Memorial Foundation, Japan/USA
Recognized for notable achievements and significant advancements in scientific research.
Publications
Overexpression of RGPR-p117 reveals anticancer effects by regulating multiple signaling pathways in bone metastatic human breast cancer MDA-MB-231 cells
Published by
IUBMB Life
Summary
Published research article.
The effects of the potent antioxidant 3,5-dihydroxy-4-methoxybenzyl alcohol on mutagenicity in microorganisms and chromosomal aberrations in cultured mammalian cells in vitro
Published by
Food and Chemical Toxicology
Summary
Published research article.
Comparative Effects of the Potent Antioxidant 3,5-Dihydroxy-4-methoxybenzyl Alcohol and Gallic Acid on the Growth and Death of RAW264.7 Macrophages and Lung Cancer A549 Cells In Vitro
Published by
Nutraceuticals
Summary
Published research article.
Assessing the toxic dose of the potent antioxidant 3,5-dihydroxy-4-methoxybenzyl alcohol in rats
Published by
Food and Chemical Toxicology
Summary
Published research article.
The Potent Antioxidant 3,5-Dihydroxy-4-Methoxybenzyl Alcohol Reveals Anticancer Activity by Targeting Several Signaling Pathways in Bone Metastatic Human Breast Cancer MDA-MB-231 Cells
Published by
Chemical Biology & Drug Design
Summary
Published research article.
The novel marine factor 3,5-dihydroxy-4-methoxybenzyl alcohol exhibits anticancer activity by regulating multiple signaling pathways in human glioblastoma cells: Blocking EGF signaling
Published by
Chemico-Biological Interactions
Summary
Published research article.
The Marine Factor 3,5-dihydroxy-4-methoxybenzyl Alcohol Suppresses Cell Growth, Inflammatory Cytokine Production, and NF-kB Signaling-enhanced Osteoclastogenesis in In vitro Mouse Macrophages RAW264.7 Cells
Published by
Current Molecular Medicine
Summary
Published research article.
The Marine Alga Sargassum horneri Is a Functional Food with High Bioactivity
Published by
Nutraceuticals
Summary
Published research article.
The Marine Alga <i>Sargassum horneri</i> Is a Functional Food with High Bioactivity
Published by
Nutraceuticals
Summary
Published research article.
The marine factor 3,5-dihydroxy-4-methoxybenzyl alcohol prevents TNF-a-mediated impairment of mineralization in mouse osteoblastic MC3T3-E1 cells: Impact of macrophage activation
Published by
Chemico-Biological Interactions
Summary
Published research article.
Regucalcin Is a Potential Regulator in Human Cancer: Aiming to Expand into Cancer Therapy
Published by
Cancers
Summary
Published research article.
Regucalcin Is a Potential Regulator in Human Cancer: Aiming to Expand into Cancer Therapy
Published by
Cancers
Summary
Published research article.
The Marine Factor 3,5-Dihydroxy-4-methoxybenzyl Alcohol Represses Adipogenesis in Mouse 3T3-L1 Adipocytes In Vitro: Regulating Diverse Signaling Pathways
Published by
Nutraceuticals
Summary
Published research article.
The Marine Factor 3,5-Dihydroxy-4-methoxybenzyl Alcohol Represses Adipogenesis in Mouse 3T3-L1 Adipocytes In Vitro: Regulating Diverse Signaling Pathways
Published by
Nutraceuticals
Summary
Published research article.
Overexpression of regucalcin blocks the migration, invasion, and bone metastatic activity of human prostate cancer cells: Crosstalk between cancer cells and bone cells
Published by
The Prostate
Summary
Published research article.
Chemical inducer of regucalcin attenuates lipopolysaccharide-induced inflammatory responses in pancreatic MIN6 B-cells and RAW264.7 macrophages
Published by
FEBS Open Bio
Summary
Published research article.
The marine factor 3,5-dihydroxy-4-methoxybenzyl alcohol suppresses growth, migration and invasion and stimulates death of metastatic human prostate cancer cells: targeting diverse signaling processes
Published by
Anti-Cancer Drugs
Summary
Published research article.
The botanical component p-hydroxycinnamic acid suppresses the growth and bone metastatic activity of human prostate cancer PC-3 cells in vitro
Published by
Journal of Cancer Research and Clinical Oncology
Summary
Published research article.
Progression-free survival of prostate cancer patients is prolonged with a higher regucalcin expression in the tumor tissues: Overexpressed regucalcin suppresses the growth and bone activity in human prostate cancer cells
Published by
Translational Oncology
Summary
Published research article.
Metaxalone Suppresses Production of Inflammatory Cytokines Associated with Painful Conditions in Mouse Macrophages RAW264.7 Cells in Vitro: Synergistic Effect with ẞ-caryophyllene
Published by
Current Molecular Medicine
Summary
Published research article.
An aryl hydrocarbon receptor agonist suppresses the growth of human umbilical vein endothelial cells in vitro: Potent effect with polyunsaturated fatty acids
Published by
International Journal of Experimental Pathology
Summary
Published research article.
Regucalcin enhances adipocyte differentiation and attenuates inflammation in 3T3-L1 cells
Published by
FEBS Open Bio
Summary
Published research article.
The calcium channel agonist Bay K 8644 promotes the growth of human liver cancer HepG2 cells in vitro: suppression with overexpressed regucalcin
Published by
Molecular and Cellular Biochemistry
Summary
Published research article.
Zinc: Characteristics, uses and benefits
Published by
Zinc: Characteristics, Uses and Benefits
Summary
Published research article.
Skills
Research & Development
Cancer Biology, Endocrinology, Cell Signaling, Molecular Metabolism, Biochemistry, Molecular Biology, Nutrition, Pharmacology, Toxicology, Bone Biology, Osteoporosis Prevention, Cancer Bone Metastasis, Drug Discovery.
Scientific Communication
Peer-Reviewed Publications, Scientific Writing, Editorial Board Leadership, Grant Writing, Conference Presentations.
Innovation & Discovery
Protein Discovery (Regucalcin), Gene Discovery (RGPR-p117), Patent Development (25 patents), Translational Research.
Academic Leadership
Teaching, Mentorship, Curriculum Development, Academic Administration, Cross-functional Collaboration.
Data Analysis
Quantitative Analysis, Experimental Design, Statistical Analysis, Scientific Method.